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Article

Malaria life cycle intensifies both natural selection and random genetic drift.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2013

Chang Hsiao-Han, Moss Eli L, Park Daniel J, Ndiaye Daouda, Mboup Souleymane, Volkman Sarah K, Sabeti Pardis C, Wirth Dyann F, Neafsey Daniel E, Hartl Daniel L

Abstract excerpt

Analysis of genome sequences of 159 isolates of Plasmodium falciparum from Senegal yields an extraordinarily high proportion (26.85%) of protein-coding genes with the ratio of nonsynonymous to synonymous polymorphism greater than one. This proportion is much greater than observed in other organisms. Also unusual is that the site-frequency spectra of synonymous and nonsynonymous polymorphisms are virtually...

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Identifiers

PMID: 24259712
DOI: 10.1073/pnas.1319857110
PMCID: PMC3864301

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