Article
Naturally acquired inhibitory antibodies to Plasmodium vivax Duffy binding protein are short-lived and allele-specific following a single malaria infection.
Clinical and experimental immunology - 1 Jun 2009
Ceravolo I P, Sanchez B A M, Sousa T N, Guerra B M, Soares I S, Braga E M, McHenry A M, Adams J H, Brito C F A, Carvalho L H
Abstract excerpt
The Duffy binding protein of Plasmodium vivax (DBP) is a critical adhesion ligand that participates in merozoite invasion of human Duffy-positive erythrocytes. A small outbreak of P. vivax malaria, in a village located in a non-malarious area of Brazil, offered us an opportunity to investigate the DBP immune responses among individuals who had their first and brief exposure to malaria. Thirty-three individuals...
Topics
- Adult
- Alleles
- Animals
- Antibodies, Protozoan
- Antigens, Protozoan
- Brazil
- Cross-Sectional Studies
- DNA, Protozoan
- Disease Outbreaks
- Humans