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Article

Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum.

Nature communications - 8 May 2018

He Qixin, Pilosof Shai, Tiedje Kathryn E, Ruybal-Pesántez Shazia, Artzy-Randrup Yael, Baskerville Edward B, Day Karen P, Pascual Mercedes

Abstract excerpt

Pathogens compete for hosts through patterns of cross-protection conferred by immune responses to antigens. In Plasmodium falciparum malaria, the var multigene family encoding for the major blood-stage antigen PfEMP1 has evolved enormous genetic diversity through ectopic recombination and mutation. With 50-60 var genes per genome, it is unclear whether immune selection can act as a dominant force in structuring...

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Identifiers

PMID: 29739937
DOI: 10.1038/s41467-018-04219-3
PMCID: PMC5940794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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