Can mutation and selection explain virulence in human P. falciparum infections?

doi:10.1186/1475-2875-3-2

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Article

Can mutation and selection explain virulence in human P. falciparum infections?

Malaria journal - 2 Mar 2004

Hastings Ian M, Paget-McNicol S, Saul A

Abstract excerpt

BACKGROUND: Parasites incur periodic mutations which must ultimately be eliminated to maintain their genetic integrity. METHODS: It is hypothesised that these mutations are eliminated not by the conventional mechanisms of competition between parasites in different hosts but primarily by competition between parasites within the same infection. RESULTS: This process is enhanced by the production of a large number...

Topics

Animals
Drug Resistance
Evolution, Molecular
Gene Frequency
Genes, Protozoan
Humans
Malaria, Falciparum
Mutation
Parasitic Sensitivity Tests
Plasmodium falciparum
Selection, Genetic
Virulence

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Identifiers

PMID: 14992697
DOI: 10.1186/1475-2875-3-2
PMCID: PMC394339

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