Article
Adaptive admixture at ACKR1, the Duffy blood group locus, may have shaped Plasmodium vivax prevalence in Oman.
American journal of human genetics - 2 Apr 2026
Haffener Paige E, Al-Riyami Arwa Z, Al-Zadjali Shoaib, Busby George B J, Al-Mahdhuri Sulaiman, Al-Rawahi Mohammed, Al-Hosni Saif, Al-Marhoobi Ali, Al-Sheriyani Ammar, Leffler Ellen M
Abstract excerpt
Malaria in humans is largely caused by two divergent species of Plasmodium parasites, P. vivax and P. falciparum, both of which have driven the spread of protective alleles in human populations. Notably, an erythrocyte-specific Duffy null allele (FyES) confers resistance to P. vivax malaria and has been identified as a target of strong, recent positive selection in multiple African-admixed populations. Here, we...
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