Article

Activation of targetable inflammatory immune signaling is seen in Myelodysplastic Syndromes with SF3B1 mutations

2022-03-09

Abstract excerpt

<h4>Background</h4> Mutations in the SF3B1 splicing factor are commonly seen in Myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML), yet the specific oncogenic pathways activated by missplicing have not been fully elucidated. Inflammatory immune pathways have been shown to play roles in pathogenesis of MDS, though the exact mechanisms of their activation in splicing mutant cases are not well understo...

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Literature Corpus work: 0ebe45b9-a816-5078-b4d8-3f6c8f5a87d2
DOI: 10.1101/2022.03.09.483595

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