Article
SF3B1 mutations constitute a novel therapeutic target in breast cancer.
The Journal of pathology - 1 Mar 2015
Maguire Sarah L, Leonidou Andri, Wai Patty, Marchiò Caterina, Ng Charlotte Ky, Sapino Anna, Salomon Anne-Vincent, Reis-Filho Jorge S, Weigelt Britta, Natrajan Rachael C
Abstract excerpt
Mutations in genes encoding proteins involved in RNA splicing have been found to occur at relatively high frequencies in several tumour types including myelodysplastic syndromes, chronic lymphocytic leukaemia, uveal melanoma, and pancreatic cancer, and at lower frequencies in breast cancer. To investigate whether dysfunction in RNA splicing is implicated in the pathogenesis of breast cancer, we performed a...
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