Article
Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation.
Science advances - 1 May 2026
Jiang Ruixin, Xing Peiqi, Xie Jindou, Bai Gang, Zhang Yuzhu, Hou Pengcong, Luo Hao, Ma Yanni, Liu Ruixin, Zheng Yang, Chen Xiangyu, Jiang Bin, Huang Jing, Zhang Yanjie, Shain A Hunter, Lei Ming, Judson-Torres Robert L, Ye Jing, Liu Zhaoqi, Zeng Hanlin
Abstract excerpt
Mutations in splicing factors are recurrent across human cancers and drive widespread RNA splicing dysregulation. Among these, SF3B1 is the most frequently mutated, yet its hotspot mutations exhibit lineage specificity, with SF3B1R625 mutations predominantly found in melanoma and SF3B1K700E in hematologic malignancies. However, the mechanistic basis for this cancer-type specificity remains unclear. Here, we...
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