Article
Distinct and convergent effects of SF3B1 mutations in human breast cancer.
Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2025
Bergman Riley E, Keeton Christin I, Sinha Irika R, Ling Jonathan P, Wang Yu, Ha Lauren, Mehta Eshani P, Reed Sarah C, Fox Ethan K, O'Grady Tina M, Yu Yingying, Fragkogianni Stamatina, Chao Calvin, Davidson Brad A, Miranda Adam X, Croessmann Sarah, Zhao Shilin, Liu Qi, Shyr Yu, Dalton W Brian, Hurley Paula J, Park Ben H
Abstract excerpt
Tumor genomic profiling has uncovered many cancer drivers whose implications in terms of tumor biology and therapeutic actionability remain understudied. Hotspot mutations in SF3B1 induce widespread transcriptomic alterations and occur across multiple cancer types. Despite this, the biological and clinical consequences of SF3B1 mutations remain elusive. Characterization of the largest SF3B1 mutant breast cancer...
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