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Article

Transcriptome sequencing reveals potential mechanism of cryptic 3' splice site selection in SF3B1-mutated cancers.

PLoS computational biology - 1 Mar 2015

DeBoever Christopher, Ghia Emanuela M, Shepard Peter J, Rassenti Laura, Barrett Christian L, Jepsen Kristen, Jamieson Catriona H M, Carson Dennis, Kipps Thomas J, Frazer Kelly A

Abstract excerpt

Mutations in the splicing factor SF3B1 are found in several cancer types and have been associated with various splicing defects. Using transcriptome sequencing data from chronic lymphocytic leukemia, breast cancer and uveal melanoma tumor samples, we show that hundreds of cryptic 3' splice sites (3'SSs) are used in cancers with SF3B1 mutations. We define the necessary sequence context for the observed cryptic 3'...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25768983
DOI: 10.1371/journal.pcbi.1004105
PMCID: PMC4358997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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