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Article

Sex-related differences in the relationship between β-amyloid and cognitive trajectories in older adults.

Neuropsychology - 1 Nov 2020

Lindbergh Cutter A, Casaletto Kaitlin B, Staffaroni Adam M, La Joie Renaud, Iaccarino Leonardo, Edwards Lauren, Tsoy Elena, Elahi Fanny, Walters Samantha M, Cotter Devyn, You Michelle, Apple Alexandra C, Asken Breton, Neuhaus John, Rexach Jessica E, Wojta Kevin J, Rabinovici Gil, Kramer Joel H

Abstract excerpt

Objective: We aimed to test the hypothesis that elevated neocortical β-amyloid (Aβ), a hallmark feature of Alzheimer's disease (AD), predicts sex-specific cognitive trajectories in clinically normal older adults, with women showing greater risk of decline than men. Method: Florbetapir Aβ positron emission tomography (PET) was acquired in 149 clinically normal older adults (52% female, Mage = 74). Participants...

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Identifiers

PMID: 33030915
DOI: 10.1037/neu0000696
PMCID: PMC7839841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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