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Distinctive Temporal Trajectories of Alzheimer’s Disease Biomarkers According to Sex and APOE Genotype: Importance of Striatal Amyloid

7 Feb 2022

Abstract excerpt

Purpose Previously, sex and apolipoprotein E ( APOE ) genotype had distinct effects on the cognitive trajectory across the Alzheimer’s disease (AD) continuum. We therefore aimed to investigate whether these trajectory curves including β-amyloid (Aβ) accumulation in the cortex and striatum, and tau accumulation would differ according to sex and APOE genotype. Methods We obtained 534 subjects for 18 F-florbetapir...

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PMID: 35197846
DOI: 10.3389/fnagi.2022.829202

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