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Evolutionary History of the Clostridium difficile Pathogenicity Locus

11 Dec 2013

Abstract excerpt

The symptoms of Clostridium difficile infection are caused by toxins expressed from its 19 kb pathogenicity locus (PaLoc). Stable integration of the PaLoc is suggested by its single chromosomal location and the clade specificity of its different genetic variants. However, the PaLoc is variably present, even among closely related strains, and thus resembles a mobile genetic element. Our aim was to explain these...

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PMID: 24336451
DOI: 10.1093/gbe/evt204

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