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Article

Clinical Clostridium difficile: clonality and pathogenicity locus diversity.

PloS one - 1 Jan 2011

Dingle Kate E, Griffiths David, Didelot Xavier, Evans Jessica, Vaughan Alison, Kachrimanidou Melina, Stoesser Nicole, Jolley Keith A, Golubchik Tanya, Harding Rosalind M, Peto Tim E, Fawley Warren, Walker A Sarah, Wilcox Mark, Crook Derrick W

Abstract excerpt

Clostridium difficile infection (CDI) is an important cause of mortality and morbidity in healthcare settings. The major virulence determinants are large clostridial toxins, toxin A (tcdA) and toxin B (tcdB), encoded within the pathogenicity locus (PaLoc). Isolates vary in pathogenicity from hypervirulent PCR-ribotypes 027 and 078 with high mortality, to benign non-toxigenic strains carried asymptomatically. The...

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Identifiers

PMID: 21625511
DOI: 10.1371/journal.pone.0019993
PMCID: PMC3098275

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