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Phylogenomics of 8,839 <i>Clostridioides difficile</i> genomes reveals recombination-driven evolution and diversification of toxin A and B

2020-07-09

Abstract excerpt

Clostridioides difficile is the major worldwide cause of antibiotic-associated gastrointestinal infection. A pathogenicity locus (PaLoc) encoding one or two homologous toxins, toxin A (TcdA) and toxin B (TcdB) is essential for C. difficile pathogenicity. However, toxin sequence variation poses major challenges for the development of diagnostic assays, therapeutics, and vaccines. Here, we present a comprehensive p...

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Literature Corpus work
19a31828-b7b1-5f37-89af-bed9e5d248f2
DOI
10.1101/2020.07.09.194449
Open publication

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Phylogenomics of 8,839 <i>Clostridioides difficile</i> genomes reveals recombination-driven evolution and diversification of toxin A and BDOI 10.1101/2020.07.09.194449
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