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Heterogeneity of large clostridial toxins: importance of<i>Clostridium difficile</i>toxinotypes

4 Apr 2008

Abstract excerpt

Clostridium difficile toxinotypes are groups of strains defined by changes in the PaLoc region encoding two main virulence factors: toxins TcdA and TcdB. Currently, 24 variant toxinotypes (I-XXIV) are known, in addition to toxinotype 0 strains, which contain a PaLoc identical to the reference strain VPI 10463. Variant toxinotypes can also differ from toxinotype 0 strains in their toxin production pattern. The...

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PMID: 18397287
DOI: 10.1111/j.1574-6976.2008.00110.x

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