Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B.

PLoS pathogens - 1 Dec 2020

Mansfield Michael J, Tremblay Benjamin J-M, Zeng Ji, Wei Xin, Hodgins Harold, Worley Jay, Bry Lynn, Dong Min, Doxey Andrew C

Abstract excerpt

Clostridioides difficile is the major worldwide cause of antibiotic-associated gastrointestinal infection. A pathogenicity locus (PaLoc) encoding one or two homologous toxins, toxin A (TcdA) and toxin B (TcdB), is essential for C. difficile pathogenicity. However, toxin sequence variation poses major challenges for the development of diagnostic assays, therapeutics, and vaccines. Here, we present a comprehensive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigenic Variation
Share to Bacterial Toxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clostridioides difficile

Share to Databases, Genetic

Share to Enterotoxins

Share to Genome, Bacterial

Share to Protein Conformation

Share to Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 33370413
DOI: 10.1371/journal.ppat.1009181
PMCID: PMC7853461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B.PMID 33370413Read ↗

Phylogenomics of 8,839 <i>Clostridioides difficile</i> genomes reveals recombination-driven evolution and diversification of toxin A and BSemantic proximity Read ↗

Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B.Semantic proximity Read ↗

Ribotype Classification of Clostridioides difficile Isolates Is Not Predictive of the Amino Acid Sequence Diversity of the Toxin Virulence Factors TcdA and TcdBSemantic proximity Read ↗

Homologous Recombination in Clostridioides difficile Mediates Diversification of Cell Surface Features and Transport Systems.Semantic proximity Read ↗

Genomic and phenotypic studies among <i>Clostridioides difficile</i> isolates show a high prevalence of clade 2 and great diversity in clinical isolates from Mexican adults and children with healthcare-associated diarrheaSemantic proximity Read ↗

Comparative genomics of Clostridioides difficile toxinotypes identifies module-based toxin gene evolutionSemantic proximity Read ↗

Genomic and phenotypic studies among Clostridioides difficile isolates show a high prevalence of clade 2 and great diversity in clinical isolates from Mexican adults and children with healthcare-associated diarrhea.Semantic proximity Read ↗

Diversity and Evolution in the Genome of Clostridium difficile.Semantic proximity Read ↗

Global Landscape of Clostridioides Difficile Phylogeography, Antibiotic Susceptibility, and Toxin Polymorphisms by Post-Hoc Whole-Genome Sequencing from the MODIFY I/II StudiesSemantic proximity Read ↗

Phylogenomic analysis of the collagen-like BclA proteins in <i>Clostridioides difficile</i>Semantic proximity Read ↗

Phylogenomic analysis of the collagen-like BclA proteins in Clostridioides difficile.Semantic proximity Read ↗

Evolutionary dynamics of Clostridium difficile over short and long time scales.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.