Article
Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: implications for protection of striatal neurons expressing mutant huntingtin.
Journal of neuroinflammation - 6 Oct 2020
Saba Julieta, López Couselo Federico, Turati Juan, Carniglia Lila, Durand Daniela, de Laurentiis Andrea, Lasaga Mercedes, Caruso Carla
Abstract excerpt
BACKGROUND: Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary cultured rat astrocytes treated with 3-nitropropionic acid (3NP), a mitochondrial toxin widely used as an in vitro model of Huntington's disease (HD). Therefore, we now investigated 3NP and BDNF...
Topics
- Animals
- Animals, Newborn
- Astrocytes
- Brain-Derived Neurotrophic Factor
- Cell Survival
- Cells, Cultured
- Cerebral Cortex
- Corpus Striatum
- Female
- Gene Expression
- Humans
- Huntingtin Protein
- Male