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Article

Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis.

Journal of neuroinflammation - 9 Jun 2010

Gandelman Mandi, Peluffo Hugo, Beckman Joseph S, Cassina Patricia, Barbeito Luis

Abstract excerpt

BACKGROUND: During pathology of the nervous system, increased extracellular ATP acts both as a cytotoxic factor and pro-inflammatory mediator through P2X(7) receptors. In animal models of amyotrophic lateral sclerosis (ALS), astrocytes expressing superoxide dismutase 1 (SOD1G93A) mutations displa...

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Source

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Identifiers

PMID: 20534165
DOI: 10.1186/1742-2094-7-33
PMCID: PMC2901222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20534165-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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