Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease.

Gene therapy - 1 Oct 2010

Giralt A, Friedman H C, Caneda-Ferrón B, Urbán N, Moreno E, Rubio N, Blanco J, Peterson A, Canals J M, Alberch J

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is the main candidate for neuroprotective therapeutic strategies for Huntington's disease. However, the administration system and the control over the dosage are still important problems to be solved. Here we generated transgenic mice overexpressing BDNF under the promoter of the glial fibrillary acidic protein (GFAP) (pGFAP-BDNF mice). These mice are viable and have a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glial Fibrillary Acidic Protein

Share to Huntington Disease

Share to Mice, Transgenic

Share to Neuroprotective Agents

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 20463759
DOI: 10.1038/gt.2010.71

Genes

BDNF
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease.PMID 20463759Read ↗

Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: implications for protection of striatal neurons expressing mutant huntingtin.Semantic proximity Read ↗

Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor.Semantic proximity Read ↗

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms.Semantic proximity Read ↗

Modified GFAP promoter auto-regulates tet-activator expression for increased transactivation and reduced tTA-associated toxicity.Semantic proximity Read ↗

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease.Semantic proximity Read ↗

Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across speciesSemantic proximity Read ↗

Expression of brain-derived neurotrophic factor in astrocytes - Beneficial effects of glatiramer acetate in the R6/2 and YAC128 mouse models of Huntington's disease.Semantic proximity Read ↗

Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington’s disease phenotypes in R6/2 miceSemantic proximity Read ↗

Optogenetic stimulation of nigral astrocytes is neuroprotective in a 6-OHDA model of neurodegenerationSemantic proximity Read ↗

Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy.Semantic proximity Read ↗

Phenotypic alteration of astrocytes induced by ciliary neurotrophic factor in the intact adult brain, As revealed by adenovirus-mediated gene transfer.Semantic proximity Read ↗

Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation stateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.