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Article

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.

Nature neuroscience - 1 May 2007

Nagai Makiko, Re Diane B, Nagata Tetsuya, Chalazonitis Alcmène, Jessell Thomas M, Wichterle Hynek, Przedborski Serge

Abstract excerpt

Mutations in superoxide dismutase-1 (SOD1) cause a form of the fatal paralytic disorder amyotrophic lateral sclerosis (ALS), presumably by a combination of cell-autonomous and non-cell-autonomous processes. Here, we show that expression of mutated human SOD1 in primary mouse spinal motor neurons does not provoke motor neuron degeneration. Conversely, rodent astrocytes expressing mutated SOD1 kill spinal primary...

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Source

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Identifiers

PMID: 17435755
DOI: 10.1038/nn1876
PMCID: PMC3799799

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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