Article
Alcohol impairs astrogliogenesis by stem cells in rodent neurospheres.
Neurochemistry international - 1 Jul 2005
Vemuri Mohan C, Chetty Chellu S
Abstract excerpt
Neurosphere cultures derived from fetal brain regions can proliferate in response to exogenous growth factors such as basic fibroblast growth factor (bFGF) and give rise to undifferentiated precursor cells that form a floating neurosphere. In this study, neurospheres generated from the ganglionic eminence region of embryonic day 15 (E15) rat embryos were treated in the presence or absence of ethanol. We found...
Topics
- Alcohol-Induced Disorders, Nervous System
- Animals
- Astrocytes
- Cell Differentiation
- Cell Lineage
- Cells, Cultured
- Central Nervous System
- Dose-Response Relationship, Drug
- Ethanol
- Female
- Fetal Alcohol Spectrum Disorders
- Neurons
- Organogenesis
- Phenotype
- Pregnancy
- Prenatal Exposure Delayed Effects
- Rats
- Rats, Sprague-Dawley
