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Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity

22 Sept 2020

Abstract excerpt

The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. Virtually all pathogenic viruses have evolved countermeasures to IFN-I restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuation. But just how important is IFN-I to antiviral defence in humans? The recent discovery of genetic defects of IFN-I signalling...

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PMID: 32977999
DOI: 10.1016/j.tig.2020.08.017

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