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Human life within a narrow range: The lethal ups and downs of type I interferons

5 Jul 2024

Abstract excerpt

The past 20 years have seen the definition of human monogenic disorders and their autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) activity. These disorders delineate the impact of type I IFNs in natural conditions and demonstrate that only a narrow window of type I IFN activity is beneficial. Insufficient type I IFN predisposes humans to life-threatening viral diseases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38968338
DOI: 10.1126/sciimmunol.adm8185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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