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The Goldilocks Zone of Type I IFNs: Lessons from Human Genetics

1 Dec 2018

Abstract excerpt

Type I IFNs (IFN-Is) are powerful cytokines. They provide remarkable protection against viral infections, but their indiscriminate production causes severe self-inflicted damage that can be lethal, particularly in early development. In humans, inappropriately high IFN-I levels caused by defects in the regulatory mechanisms that control IFN-I production and response result in clinical conditions known as type I...

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PMID: 30530500
DOI: 10.4049/jimmunol.1800764

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