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Article

Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway.

European journal of immunology - 1 May 2021

Meyts Isabelle, Casanova Jean-Laurent

Abstract excerpt

Type I IFNs are so-named because they interfere with viral infection in vertebrate cells. The study of cellular responses to type I IFNs led to the discovery of the JAK-STAT signaling pathway, which also governs the response to other cytokine families. We review here the outcome of viral infections in mice and humans with engineered and inborn deficiencies, respectively, of (i) IFNAR1 or IFNAR2, selectively...

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Identifiers

PMID: 33729549
DOI: 10.1002/eji.202048793
PMCID: PMC8900014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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