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Article

Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense.

Immunological reviews - 1 Dec 2008

Zhang Shen-Ying, Boisson-Dupuis Stéphanie, Chapgier Ariane, Yang Kun, Bustamante Jacinta, Puel Anne, Picard Capucine, Abel Laurent, Jouanguy Emmanuelle, Casanova Jean-Laurent

Abstract excerpt

Interferon (IFN) was originally identified as a substance 'interfering' with viral replication in vitro. The first IFNs to be identified were classified as type I IFNs (IFN-alpha/beta and related molecules), two other types have since been identified: type II IFN (IFN-gamma) and type III IFNs (IFN-lambda). Each IFN binds to one of three type-specific receptors. In the mouse model of experimental infections in...

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Source

Identifiers

PMID: 19161414
DOI: 10.1111/j.1600-065X.2008.00698.x

Genes

STAT1
IFNGR1
IFNGR2
TLR3
TYK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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