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Article

Host genetic susceptibility to viral infections: the role of type I interferon induction.

Genes and immunity - 1 Dec 2020

Bourdon Marie, Manet Caroline, Montagutelli Xavier

Abstract excerpt

The innate immune response is the major front line of defense against viral infections. It involves hundreds of genes with antiviral properties which expression is induced by type I interferons (IFNs) and are therefore called interferon stimulated genes (ISGs). Type I IFNs are produced after viral recognition by pathogen recognition receptors, which trigger a cascade of activation events. Human and mouse studies...

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PMID: 33219336
DOI: 10.1038/s41435-020-00116-2
PMCID: PMC7677911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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