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Article

Hyperosmolar Ionic Solutions Modulate Inflammatory Phenotype and sGAG Loss in a Cartilage Explant Model.

Cartilage - 1 Dec 2021

Arabiyat Ahmad S, Chen Hongyu, Erndt-Marino Josh, Burkhard Katie, Scola Lisa, Fleck Allison, Wan Leo Q, Hahn Mariah S

Abstract excerpt

OBJECTIVE: The objective of this study was to compare the effects of hyperosmolar sodium (Na+), lithium (Li+) and potassium (K+) on catabolic and inflammatory osteoarthritis (OA) markers and sulfated glycosaminoglycan (sGAG) loss in TNF-α-stimulated cartilage explants. METHODS: Explants from bovine stifle joints were stimulated with TNF-α for 1 day to induce cartilage degradation followed by supplementation with...

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Identifiers

PMID: 32975437
DOI: 10.1177/1947603520961167
PMCID: PMC8804856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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