Article
Physiological tonicity improves human chondrogenic marker expression through nuclear factor of activated T-cells 5 in vitro.
Arthritis research & therapy - 1 Jan 2010
van der Windt Anna E, Haak Esther, Das Ruud H J, Kops Nicole, Welting Tim J M, Caron Marjolein M J, van Til Niek P, Verhaar Jan A N, Weinans Harrie, Jahr Holger
Abstract excerpt
INTRODUCTION: Chondrocytes experience a hypertonic environment compared with plasma (280 mOsm) due to the high fixed negative charge density of cartilage. Standard isolation of chondrocytes removes their hypertonic matrix, exposing them to nonphysiological conditions. During in vitro expansion, chondrocytes quickly lose their specialized phenotype, making them inappropriate for cell-based regenerative strategies....
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