Article
Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican.
Cells - 13 Jul 2020
Xue Jiapeng, Chen Jinnan, Shen Quan, Chan Deva, Li Jun, Tanguay Adam P, Schmidt Tannin A, Niazi Faizan, Plaas Anna
Abstract excerpt
We have examined the effect of exogenous linear chain high molecular weight hyaluronic acid (HMW HA) on endogenously synthesized hyaluronic acid (HA) and associated binding proteins in primary cultures of fibroblast-like stromal cells that were obtained by collagenase digestion of the murine peripatellar fat pad. The cultures were expanded in DMEM that was supplemented with fetal bovine serum and basic fibroblast...
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