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Article

MAIT cells and viruses

19 Jan 2018

Abstract excerpt

Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially derived metabolites. Functionally, they respond to bacteria and yeasts, which possess the riboflavin pathway, essential for production of such metabolites and which are presented on MR1. Viruses cannot generate these ligands, so a priori, they should not be recognized by MAIT cells and indeed this...

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PMID: 29350807
DOI: 10.1111/imcb.12008

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