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Article

Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice

21 Aug 2020

Abstract excerpt

Emerging data indicate that free heme promotes inflammation in many different disease settings, including in sickle cell disease (SCD). Although free heme, proinflammatory cytokines and cardiac hypertrophy are co-existing features of SCD, no mechanistic links between these features have been demonstrated. We now report significantly higher levels of IL-6 mRNA and protein in hearts of the Townes sickle cell...

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PMID: 32973791
DOI: 10.3389/fimmu.2020.01910

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