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Article

Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease.

Blood - 15 Feb 2006

Manci Elizabeth A, Hillery Cheryl A, Bodian Carol A, Zhang Zheng G, Lutty Gerard A, Coller Barry S

Abstract excerpt

Because Berkeley sickle cell mice are used as an animal model for human sickle cell disease, we investigated the progression of the histopathology in these animals over 6 months and compared these findings to those published in humans with sickle cell disease. The murine study groups were composed of wild-type mixed C57Bl/6-SV129 (control) mice and sickle cell (SS) mice (alpha-/-, beta-/-, transgene +) of both...

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Identifiers

PMID: 16166585
DOI: 10.1182/blood-2005-07-2839
PMCID: PMC1895417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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