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Article

Inflammatory and oxidative stress phenotypes in transgenic sickle cell mice.

Blood cells, molecules & diseases - 1 Nov 2016

Charrin Emmanuelle, Ofori-Acquah Solomon Fiifi, Nader Elie, Skinner Sarah, Connes Philippe, Pialoux Vincent, Joly Philippe, Martin Cyril

Abstract excerpt

The Townes mouse model of homozygous sickle cell disease (SS) has emerged as the major experimental model for studying pathophysiological mechanisms of human sickle cell disease (SCD). We therefore investigated hematological and hemorheological parameters as well as organ-specific inflammatory and oxidative stress molecular profiles in these animals in steady state conditions. Evidences of SCD-related...

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Source

Identifiers

PMID: 27835777
DOI: 10.1016/j.bcmd.2016.10.020

Genes

SCD
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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