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Long Non-Coding RNA MALAT1 Regulates HMOX1 in Sickle Cell Disease-Associated Pulmonary Hypertension

2025-10-07

Abstract excerpt

Pulmonary hypertension (PH) causes morbidity and mortality in sickle cell disease (SCD). The release of heme during hemolysis triggers endothelial dysfunction and contributes to PH. Long non-coding RNAs (lncRNAs) may play a pivotal role in endo-thelial dysfunction and PH pathogenesis. This study assessed the regulatory role of the lncRNA heme oxygenase-1 (HMOX1) axis in SCD-PH pathogenesis. Total RNAs were isolate...

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Literature Corpus work
3a3d0430-322a-53c5-85b3-12b010fec1fd
DOI
10.20944/preprints202510.0503.v1
Open publication

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Long Non-Coding RNA MALAT1 Regulates HMOX1 in Sickle Cell Disease-Associated Pulmonary HypertensionDOI 10.20944/preprints202510.0503.v1
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