Article

Life-long hydroxyurea treatment decreases chronic pain in sickle cell disease mice

2025-09-03

Abstract excerpt

Chronic sickle cell disease (SCD) pain mechanisms remain critically understudied, even though more than 50% of patients develop this symptom as their disease progresses. Despite high face validity, there are critical gaps in transgenic SCD mouse model characterization and implementation that must be addressed in order to increase the translational relevance of these animals. First, it is unclear when the chronic p...

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Literature Corpus work: d9d2cc13-c34d-5918-8e56-26e39527820e
DOI: 10.1101/2025.08.30.673263

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