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Article

The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1.

Science (New York, N.Y.) - 1 Sept 2006

Yi Peng, Han Zhe, Li Xiumin, Olson Eric N

Abstract excerpt

The early morphogenetic mechanisms involved in heart formation are evolutionarily conserved. A screen for genes that control Drosophila heart development revealed a cardiac defect in which pericardial and cardial cells dissociate, which causes loss of cardiac function and embryonic lethality. This phenotype resulted from mutations in the genes encoding HMG-CoA reductase, downstream enzymes in the mevalonate...

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Source

Identifiers

PMID: 16857902
DOI: 10.1126/science.1127704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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