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Article

Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects.

Clinical pharmacology and therapeutics - 1 Mar 2021

Bauer Martin, Bamminger Karsten, Pichler Verena, Weber Maria, Binder Simon, Maier-Salamon Alexandra, Tahir Ammar, Jäger Walter, Haslacher Helmuth, Tournier Nicolas, Hacker Marcus, Zeitlinger Markus, Langer Oliver

Abstract excerpt

The antiemetic and gastroprokinetic drug metoclopramide is a weak substrate of the blood-brain barrier (BBB) efflux transporter P-gp and displays central nervous system (CNS) side effects (i.e., extrapyramidal symptoms and tardive dyskinesia) caused by dopamine D2 receptor blockade in the basal ganglia. These side effects occur with a higher incidence in elderly people. We used positron emission tomography to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32966590
DOI: 10.1002/cpt.2052
PMCID: PMC7983943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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