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Article

No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.

Clinical pharmacology and therapeutics - 1 Nov 2003

Pauli-Magnus Christiane, Feiner John, Brett Claire, Lin Emil, Kroetz Deanna L

Abstract excerpt

BACKGROUND: The MDR1 gene encodes the efflux transporter P-glycoprotein, which is highly expressed in the small intestine and in the blood-brain barrier. A major function of P-glycoprotein is to limit the absorption and central nervous system exposure of numerous xenobiotics. A genetic polymorphism in the MDR1 gene (C3435T) has been associated with changes in the intestinal expression level and function of...

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Identifiers

PMID: 14586389
DOI: 10.1016/S0009-9236(03)00234-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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