Article
The pharmacokinetics of pergolide in Parkinson's disease.
Current opinion in neurology - 1 Dec 2003
Blin Olivier
Abstract excerpt
Three decades of research have led to a fuller understanding of the pharmacokinetics of pergolide. Pergolide is rapidly absorbed following oral dosing, reaching peak plasma concentrations within 2-3 h. It is about 90% protein bound yet has negligible drug interactions. Pergolide undergoes extensive first-pass metabolism and is completely eliminated within 4-5 days. The metabolism/elimination profile varies...
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