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Article

The role of the efflux transporter, P‐glycoprotein, at the blood–brain barrier in drug discovery

6 Oct 2022

Abstract excerpt

The blood-brain barrier (BBB) expresses a high abundance of transporters, particularly P-glycoprotein (P-gp), that regulate endogenous and exogenous molecule uptake and removal of waste. This review discusses key drug metabolism and pharmacokinetic considerations for the efflux transporter P-gp at the BBB in drug discovery and development. We highlight the differences in P-gp expression and protein levels across...

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PMID: 36198662
DOI: 10.1002/bdd.2331

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