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Radiopharmaceuticals for assessing ABC transporters at the blood–brain barrier

11 Feb 2015

Abstract excerpt

ABC transporters protect the brain by transporting neurotoxic compounds from the brain back into the blood. P-glycoprotein (P-gp) is the most investigated ABC (efflux) transporter, as it is implicated in neurodegenerative diseases such as Alzheimer's disease. Altered function of P-gp can be studied in vivo, using Positron Emission Tomography (PET). To date, several radiopharmaceuticals have been developed to...

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PMID: 25669763
DOI: 10.1002/cpt.73

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