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Article

Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography.

Clinical pharmacology and therapeutics - 1 Jun 2006

Toornvliet Rolf, van Berckel Bart N M, Luurtsema Gert, Lubberink Mark, Geldof Albert A, Bosch Tessa M, Oerlemans Ruud, Lammertsma Adriaan A, Franssen Eric J F

Abstract excerpt

INTRODUCTION: P-glycoprotein (P-gp) is an efflux transporter responsible for the transport of various drugs across the blood-brain barrier (BBB). Loss of P-gp function with age may be one factor in the development and progression of neurodegenerative diseases. The aim of this study was to assess the effect of aging on BBB P-gp function. Furthermore, the relationship between BBB P-gp activity and peripheral P-gp...

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Identifiers

PMID: 16765142
DOI: 10.1016/j.clpt.2006.02.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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