Article

Parametric imaging of P-glycoprotein function at the blood-brain barrier using kE,brain-maps generated from [11C]metoclopramide PET data in rats, nonhuman primates and humans

2023-05-22

Abstract excerpt

<title>Abstract</title> Purpose PET imaging using [11C]metoclopramide revealed the importance of P-glycoprotein (P-gp, ABCB1) in mediating the brain-to-blood efflux of substrates across the blood-brain barrier (BBB). In this work, the elimination rate constant from the brain (<italic>k</italic>E,brain), calculated from dynamic PET images without the need for arterial blood sampling, was...

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Literature Corpus work: 87552de8-c789-5a83-bd4a-9be1896c7b92
DOI: 10.21203/rs.3.rs-2920574/v1

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Parametric imaging of P-glycoprotein function at the blood-brain barrier using kE,brain-maps generated from [11C]metoclopramide PET data in rats, nonhuman primates and humansDOI 10.21203/rs.3.rs-2920574/v1Read

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