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Article

Pharmacokinetics of oltipraz in mutant Nagase analbuminemic rats.

Journal of pharmaceutical sciences - 1 May 2006

Bae Soo K, Kang Hee E, Kang Min K, Kim Jin W, Kim Taekrho, Lee Myung G

Abstract excerpt

Pharmacokinetic parameters of oltipraz were compared after intravenous (10 mg/kg) and oral (50 mg/kg) administration to control male Sprague-Dawely rats and mutant Nagase analbuminemic rats (NARs). In NARs, the expression and mRNA level of CYP1A2 increased, and oltipraz was mainly metabolized via CYP1A1/2, 2B1/2, 2C11, 201, and 3A1/2 in male rats. Hence, it may be expected that the CL of oltipraz would be...

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PMID: 16544321
DOI: 10.1002/jps.20602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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