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Article

Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing.

Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2014

Zvyagin Ivan V, Pogorelyy Mikhail V, Ivanova Marina E, Komech Ekaterina A, Shugay Mikhail, Bolotin Dmitry A, Shelenkov Andrey A, Kurnosov Alexey A, Staroverov Dmitriy B, Chudakov Dmitriy M, Lebedev Yuri B, Mamedov Ilgar Z

Abstract excerpt

Adaptive immunity in humans is provided by hypervariable Ig-like molecules on the surface of B and T cells. The final set of these molecules in each organism is formed under the influence of two forces: individual genetic traits and the environment, which includes the diverse spectra of alien and self-antigens. Here we assess the impact of individual genetic factors on the formation of the adaptive immunity by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to High-Throughput Nucleotide Sequencing

Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 24711416
DOI: 10.1073/pnas.1319389111
PMCID: PMC4000852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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