Article
An integrated germline and somatic genomic model for coronary artery disease.
Nature communications - 26 Mar 2026
Yang Xiong, Kim Min Seo, Zhu Xinyu, Uddin Md Mesbah, Nakao Tetsushi, Cho So Mi Jemma, Koyama Satoshi, Xu Tingfeng, Reeskamp Laurens F, Zhang Rufan, Liu Zhaoqi, A Yunga, de Vries Paul S, Vasan Ramachandran S, Boerwinkle Eric, Morrison Alanna C, Psaty Bruce M, Tracy Russell P, Heckbert Susan R, Cho Michael H, Yun Jeong H, Palmer Nicholette D, Bowden Donald W, Murabito Joanne M, Levy Daniel, Heard-Costa Nancy L, O'Connor George T, Becker Lewis C, Kral Brian G, Yanek Lisa R, Raffield Laura M, Hidalgo Bertha, Rotter Jerome I, Rich Stephen S, Taylor Kent D, Post Wendy S, Kooperberg Charles, Reiner Alexander P, Mitchell Braxton D, Kardia Sharon L R, Smith Jennifer A, Peyser Patricia A, Bielak Lawrence F, Yon Dong Keon, Won Hong-Hee, Arnett Donna K, Smith Albert V, Gabriel Stacey B, Ellinor Patrick T, Natarajan Pradeep, Wang Minxian, Fahed Akl C
Abstract excerpt
Multiple germline and somatic genomic factors are associated with risk of coronary artery disease, but there is no single measure of risk that integrates all information from a DNA sample. To address this gap, we develop an integrated genomic model that includes six germline and somatic genetic drivers for coronary artery disease, including polygenic risk score, genetically-proxied proteomic/metabolomic risk...
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