Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults.

doi:10.1093/cercor/bhaa251

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Article

Sex-Dependent Effects of the APOE ɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults.

Cerebral cortex (New York, N.Y. : 1991) - 1 Jan 2021

Takeuchi Hikaru, Tomita Hiroaki, Browne Ryan, Taki Yasuyuki, Kikuchi Yoshie, Ono Chiaki, Yu Zhiqian, Nouchi Rui, Yokoyama Ryoichi, Kotozaki Yuka, Nakagawa Seishu, Sekiguchi Atsushi, Iizuka Kunio, Hanawa Sugiko, Araki Tsuyoshi, Miyauchi Carlos Makoto, Sakaki Kohei, Nozawa Takayuki, Ikeda Shigeyuki, Yokota Susumu, Magistro Daniele, Sassa Yuko, Kawashima Ryuta

Abstract excerpt

The APOE ɛ4 allele is associated with a risk of Alzheimer's disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ɛ4 allele in young adults are mixed. Here, we investigated the sex-genotype interaction effects of the APOE ɛ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple...

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Identifiers

PMID: 32954402
DOI: 10.1093/cercor/bhaa251
PMCID: PMC7727389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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