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Article

USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2

18 Sept 2020

Abstract excerpt

in melanoma stimulates chemokine expression and TILs in a TET2-dependent manner, leading to increased response to immunotherapy and extended life span of tumor-bearing mice. These results reveal a previously unknown regulator of TET2 activity and suggest USP15 as a potential therapeutic target for immunotherapy of solid tumors.

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Identifiers

PMID: 32948596
DOI: 10.1126/sciadv.abc9730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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